Cholesterol, 95%, Thermo Scientific Chemicals

Name: Cholesterol, 95%, Thermo Scientific Chemicals
SKU: A11470.0B

A laboratory purified preparation of the animal sterol, Cholesterol, CAS # 57-88-5, is available in powder form for experimental use.

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Catalog number A11470.0B

also known as A11470-0B

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Quantity:

1000 g

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Chemical Identifiers

CAS57-88-5

IUPAC Name(1R,3aS,3bS,7S,9aR,9bS,11aR)-9a,11a-dimethyl-1-[(2R)-6-methylheptan-2-yl]-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-7-ol

Molecular FormulaC27H46O

InChI KeyHVYWMOMLDIMFJA-DPAQBDIFSA-N

SMILESCC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

Specifications

Specification Sheet

Appearance (Color)White

FormCrystals or powder or crystalline powder

Assay (GC)≥94.0%

Identification (FTIR)Conforms

Cholesterol is used in the preparation of liposome. It is used to control the functions of transporters and coordinating cell proteins present in plasma membrane. It acts as a part of cell membranes. It benefits in rapid diagnostics. It is a component of all biological membranes and inhibits basal channel activity in the brain.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General description

Cholesterol (cholesterin, cholesteryl alcohol) is a lipid sterol found in vertebrate cell membranes
Cholesterol is a cholestanoid, a class of molecule that contains the C-27 cholestane motif
A precursor of many steroids and sex hormones in animals including cortisol, aldosterone, testosterone, progesterone, and estrogen
It plays a role in neurotransmission and is crucial for organ systems, such as immune, reproductive and endocrine systems

Applications

Suitable for in vitro and in vivo applications
Stabilized in powder form for laboratory use only

RUO – Research Use Only

General References:

Nierzwicki, L.; Czub, J. Specific Binding of Cholesetrol to the Amyloid Precursor Protein: Structure of the Complex and Driving Forces Characterized in Molecular Detail. J. Phys. Chem. Lett. 2015, 6 (5), 784-790.
Lee, S. S.; Li, J.; Tai, J. N.; Ratliff, T. L.; Park, K.; Cheng, J. Avasimibe Encapsulated in Human Serum Albumin Blocks Cholesterol Esterification for Selective Cancer Treatment. ACS Nano. 2015, 9 (3), 2420-2432.