Ethyl cyanoacetate, 98+%, Thermo Scientific Chemicals
Element SearchElement SearchStructure SearchStructure Search
Ethyl cyanoacetate, 98+%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Ethyl cyanoacetate, 98+%, Thermo Scientific Chemicals

Have Questions?
Change viewbuttonViewtableView
Quantity:
2500 g
500 g
ChemDexTry the chem dexTM web app
Catalog number A11498.0E
also known as A11498-0E
Price (USD)/ Each
168.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
198.00 
Save 29.35 (15%)
-
Add to cart
Quantity:
2500 g
Request bulk or custom format
Price (USD)/ Each
168.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
198.00 
Save 29.35 (15%)
Add to cart
Ethyl cyanoacetate, 98+%, Thermo Scientific Chemicals
Catalog numberA11498.0E
Price (USD)/ Each
168.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
198.00 
Save 29.35 (15%)
-
Add to cart
Chemical Identifiers
CAS105-56-6
IUPAC Nameethyl 2-cyanoacetate
Molecular FormulaC5H7NO2
InChI KeyZIUSEGSNTOUIPT-UHFFFAOYSA-N
SMILESCCOC(=O)CC#N
View more
SpecificationsSpecification SheetSpecification Sheet
FormLiquid
Assay (GC)≥98.0%
Appearance (Color)Clear colorless
Identification (FTIR)Conforms
Refractive Index1.4160-1.4200 @ 20?C
Cyanoacetate is a building block for the synthesis of heterocycles and are are used as drugs. It is also used as Pharmaceutical intermediates, or Oil soluble couplers of film raw material . It is also used as a reagent in labelled pyrimidine and purine synthesis. It is used as an intermediate of fine chemicals such as medicine and dyestuff.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Cyanoacetate is a building block for the synthesis of heterocycles and are are used as drugs. It is also used as Pharmaceutical intermediates, or Oil soluble couplers of film raw material . It is also used as a reagent in labelled pyrimidine and purine synthesis. It is used as an intermediate of fine chemicals such as medicine and dyestuff.

Solubility
It is slightly soluble in water. Mostly soluble in organic solvents such as chloroform, ethyl acetate.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible materials strong acids, strong bases, strong oxidizing agents, strong reducing agents.
RUO – Research Use Only

General References:

  1. Jose A. Cabello.; Juan M. Campelo.; Angel Garcia.; Diego Luna.; Jose M. Marinas. Knoevenagel condensation in the heterogeneous phase using aluminum phosphate-aluminum oxide as a new catalyst. J. Org. Chem. 1984, 49, (26), 5195-5197.Rajendra K. Singh.; Samuel Danishefsky. Preparation of activated cyclopropanes by phase transfer alkylation. J. Org. Chem. 1975, 40, (20), 2969-2970.
  2. Stereoselective alkylation of the active methylene has been accomplished under particularly mild conditions with secondary alkyl mesylates in the presence of CsF in DMF; complete inversion occurs at the secondary alkyl carbon: J. Org. Chem., 60, 2627 (1995).
  3. Arylation by aryl iodides is promoted by copper(I) iodide: Synthesis, 67 (1983); J. Org. Chem., 58, 7606 (1993); or trans-Dichlorobis(triphenyl phosphine) palladium(II) , 10491: Synthesis, 506 (1985).
  4. For examples of Knoevenagel condensations of cyanoacetic esters with carbonyl compounds, see: Org. Synth. Coll., 3, 385, 399 (1955); 4, 93, 463 (1963); review: Org. React., 15, 204 (1967). Knoevenagel condensation with aromatic aldehydes has also been carried out under acidic conditions, for example, good yields have been obtained with ZnCl2: Tetrahedron Lett., 32, 5821 (1991).
  5. For use in the synthesis of pyrrole derivatives, see p-Toluenesulfonyl methyl isocyanide, A14312.