2-Fluoropyridine is a useful precursor of 2,3-disubstituted pyridines which is made by the possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine. It can also react with thiophene to get 2-thiophen-2-yl-pyridine. It is used in the synthesis of aminopyridines.
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Applications
2-Fluoropyridine is a useful precursor of 2,3-disubstituted pyridines which is made by the possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine. It can also react with thiophene to get 2-thiophen-2-yl-pyridine. It is used in the synthesis of aminopyridines.
Solubility
Soluble in water.
Notes
Store in a cool, dry, well-ventilated area away from incompatible substances such as oxidizing agents.
RUO – Research Use Only
General References:
- Lubov Pasumansky; Armando R. Hernández; Soya Gamsey; Christian T. Goralskib; Bakthan Singaram. Synthesis of aminopyridines from 2-fluoropyridine and lithium amides. Tetrahedron Letters.2004, 45 413-417.
- The possibility of metallation at C-3, together with the ready nucleophilic displacement of the activated fluorine makes 2-fluoropyridine a useful precursor of a wide range of 2,3-disubstituted pyridines. See, e.g.: J. Org. Chem., 53, 2740 (1988):