Ethyl 2-methylacetoacetate is used in Japp-Klingemann reaction to prepare hydrazones from beta-keto acid and aryl diazonium salts. It is used as a precursor involved in the synthesis of ethylpyruvate phenylhydrazone via reaction with benzenediazonium chloride.
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Applications
Ethyl 2-methylacetoacetate is used in Japp-Klingemann reaction to prepare hydrazones from beta-keto acid and aryl diazonium salts. It is used as a precursor involved in the synthesis of ethylpyruvate phenylhydrazone via reaction with benzenediazonium chloride.
Solubility
Miscible with alcohol and ether. Silghtly miscible with water.
Notes
Incompatible with strong oxidizing agents and strong bases.
RUO – Research Use Only
General References:
- Kula, S.; Szlapa, A.; Malecki, J. G.; Maron, A.; Matussek, M.; Balcerzak, E. S.; Siwy, M.; Domanski, M.; Sojka, M.; Danikiewicz, W.; Krompiec, S.; Filapek, M. Synthesis and photophysical properties of novel multisubstituted benzene and naphthalene derivatives with high 2D-pi-conjugation. Opt. Mater. 2015, 47, 118-128.
- Hatamur, M.; Yamaguchi, S.; Takane, S.; Chen, Y.; Suganuma, K. Decarboxylation and simultaneous reduction of silver(I) beta-ketocarboxylates with three. Dalton Trans. 2015, 44 (19), 8993-9003.