1-Bromo-2-chlorobenzene finds application in Gas Chromatography and Liquid Chromatography analysis. It is also used as an intermediate in pharmaceutical and synthetic chemistry. Further, it acts as a reagent in the preparation of arylpiperidines and aryltetrahydropyridines as 5-HT
2C agonists.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
1-Bromo-2-chlorobenzene finds application in Gas Chromatography and Liquid Chromatography analysis. It is also used as an intermediate in pharmaceutical and synthetic chemistry. Further, it acts as a reagent in the preparation of arylpiperidines and aryltetrahydropyridines as 5-HT2C agonists.
Solubility
Immiscible with water.
Notes
Store in a cool place. Incompatible with strong oxidizing agents.
RUO – Research Use Only
Lithiation with LDA occurs ortho to the chlorine atom; subsequent reaction with electrophiles provides access to mixed dihalo derivatives such as 3-bromo-2-chlorobenzoic acid: Tetrahedron Lett., 36, 881 (1995).
Chen, J.; Natte, K.; Wu, X. F. Convenient palladium-catalyzed carbonylative synthesis of caprolactam and butyrolactam derived phthalimides and amides by using DBU and DBN as the nitrogen source. Tetrahedron Lett. 2015, 56 (2), 342-345.
Gao, J.; Zhu, J.; Chen, L.; Shao, Y.; Zhu, J.; Huang, Y.; Wang, X.; Lv, X. Synthesis of benzimidazo[2,1-b]benzothiazole derivatives through sequential Cu-catalyzed domino coupling and Pd-catalyzed Suzuki reaction. Tetrahedron Lett. 2014, 55 (22), 3367-3373.