2-bromoacetophenone is employed in the selective derivatization of cytosine moieties for the determination of global DNA methylation by reversed phase high performance liquid chromatography with spectrofluorimetric detection.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
2-bromoacetophenone is employed in the selective derivatization of cytosine moieties for the determination of global DNA methylation by reversed phase high performance liquid chromatography with spectrofluorimetric detection.
Solubility
Insoluble in water.
Notes
Store in cool place. Keep away from oxidizing agents.
RUO – Research Use Only
General References:
- Adolfo Lopez Torres.; Eunice Yanez Barrientos.; Katarzyna Wrobel.; Kazimierz Wrobel. Selective Derivatization of Cytosine and Methylcytosine Moieties with 2-Bromoacetophenone for Submicrogram DNA Methylation Analysis by Reversed Phase HPLC with Spectrofluorimetric Detection.Anal. Chem. 2011, 83 (20),7999-8005.
- S. Ramalingam.;P. Anbusrinivasan.; S. Periandy. FT-IR and FT-Raman spectral investigation, computed IR intensity and Raman activity analysis and frequency estimation analysis on 4-chloro-2-bromoacetophenone using HF and DFT calculations.Spectrochim. Acta, Part A. 2011, 78 (2),826-834.