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p-Toluenesulfonamide, 98+%, Thermo Scientific Chemicals
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Catalog number A12156.36
also known as A12156-36
Price (USD)/ Each
47.50
-
Quantity:
500 g
Price (USD)/ Each
47.50
p-Toluenesulfonamide, 98+%, Thermo Scientific Chemicals
Catalog numberA12156.36
Price (USD)/ Each
47.50
-
Chemical Identifiers
CAS70-55-3
IUPAC Name4-methylbenzene-1-sulfonamide
Molecular FormulaC7H9NO2S
InChI KeyLMYRWZFENFIFIT-UHFFFAOYSA-N
SMILESCC1=CC=C(C=C1)S(N)(=O)=O
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Specifications
Specification Sheet
Specification SheetFormCrystals or powder or crystalline powder
Identification (FTIR)Conforms
Appearance (Color)White
Assay (GC)≥98.0%
Solution Test5% in Ethanol: clear
p-Toluene sulfonamide was used to prepare the precursor required for synthesis of ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate. It act as a derivative of ammonia activated to alkylation by alkyl halides is exemplified by the synthesis of N-tosyl-2,3-dihydroisoindole from o-xylylene dibromide. It is a precursor of N-tosyl imines.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
p-Toluene sulfonamide was used to prepare the precursor required for synthesis of ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate. It act as a derivative of ammonia activated to alkylation by alkyl halides is exemplified by the synthesis of N-tosyl-2,3-dihydroisoindole from o-xylylene dibromide. It is a precursor of N-tosyl imines.
Solubility
Soluble in water.
Notes
Store in cool, dry place, in well sealed container. Store away from oxidizing agents.
p-Toluene sulfonamide was used to prepare the precursor required for synthesis of ethyl 6-phenyl-1-tosyl-1,2,5,6-tetrahydropyridine-3-carboxylate. It act as a derivative of ammonia activated to alkylation by alkyl halides is exemplified by the synthesis of N-tosyl-2,3-dihydroisoindole from o-xylylene dibromide. It is a precursor of N-tosyl imines.
Solubility
Soluble in water.
Notes
Store in cool, dry place, in well sealed container. Store away from oxidizing agents.
RUO – Research Use Only
General References:
- Kui Lu; Ohyun Kwon. Phosphine-Catalyzed [4+2] Annulation: Synthesis of Ethyl 6-Phenyl-1-Tosyl-1,2,5,6-Tetrahydropyridine-3-Carboxylate. Organic Syntheses. 2009, 2009 (86), 212-224.
- D. S. Tarbell; Clay Weaver. The Condensation of Sulfoxides with p-Toluenesulfonamide and Substituted Acetamides. J. Am. Chem. Soc. 1941, 63 (11), 2939-2942.
- Use of p-toluenesulfonamide as a derivative of ammonia activated to alkylation by alkyl halides is exemplified by the synthesis of N-tosyl-2,3-dihydroisoindole from o-xylylene dibromide: Org. Synth. Coll., 5, 1064 (1973). Similarly, has been used as the precursor of nitrogen-containing crown ethers; see, e.g.: J. Org. Chem., 53, 5292 (1988).
- Precursor of N-tosyl imines, which are useful intermediates in synthesis: Synlett, 2097 (2003).