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6-Mercaptopurine monohydrate, 98%, Thermo Scientific Chemicals
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Catalog number A12197.14
also known as A12197-14
Price (USD)/ Each
237.65
Online exclusive
264.00 Save 26.35 (10%)
-
Quantity:
25 g
Price (USD)/ Each
237.65
Online exclusive
264.00 Save 26.35 (10%)
6-Mercaptopurine monohydrate, 98%, Thermo Scientific Chemicals
Catalog numberA12197.14
Price (USD)/ Each
237.65
Online exclusive
264.00 Save 26.35 (10%)
-
Chemical Identifiers
CAS6112-76-1
IUPAC Name6,7-dihydro-3H-purine-6-thione hydrate
Molecular FormulaC5H6N4OS
InChI KeyWFFQYWAAEWLHJC-UHFFFAOYSA-N
SMILESO.S=C1N=CNC2=C1NC=N2
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Specifications
Specification Sheet
Specification SheetAppearance (Color)Yellow
Assay (HPLC)≥97.5%
Loss on Drying5.59-15.08% (200?C/constant weight) (0.5-1.5 waters)
FormPowder
6-Mercaptopurine is a widely used antileukemic agent that inhibits de novopurine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. It is also an antitumor agent and induces apoptosis.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
6-Mercaptopurine is a widely used antileukemic agent that inhibits de novopurine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. It is also an antitumor agent and induces apoptosis.
Solubility
Soluble in dilute solutions of alkali hydroxides, hot alcohol, and 1 N NaOH (50 mg/ml). Insoluble in water.
Notes
Store in cool, dry place, in well sealed container. Store away from oxidizing agents.
6-Mercaptopurine is a widely used antileukemic agent that inhibits de novopurine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA. It is also an antitumor agent and induces apoptosis.
Solubility
Soluble in dilute solutions of alkali hydroxides, hot alcohol, and 1 N NaOH (50 mg/ml). Insoluble in water.
Notes
Store in cool, dry place, in well sealed container. Store away from oxidizing agents.
WARNING: Reproductive Harm - www.P65Warnings.ca.gov
RUO – Research Use Only
General References:
- K. D. Senali Abayratna Wansa; Jonathan M. Harris; Grace Yan; Peter Ordentlich and George E. O. Muscat. The AF-1 Domain of the Orphan Nuclear Receptor NOR-1 Mediates Trans-activation, Coactivator Recruitment, and Activation by the Purine Anti-metabolite 6-Mercaptopurine. The Journal of Biological Chemistry. 1986, 278, 24776-24790.
- John A. Montgomery; Thomas P. Johnston; Anne Gallagher; Carl R. Stringfellow; Frank M. SchabelJr. A Comparative Study of the Anticancer Activity of Some S-Substituted Derivatives of 6-Mercaptopurine and their Ribonucleosides. J. Med. Chem. 1960, 3 (2), 265-288.