2-Bromotoluene was used in the synthesis of (±)-isocomene. Suzuki coupling of 2-bromotoluene with phenylboronic acid using palladium nanoparticles supported on alumina-based oxides as catalyst has been reported. 2-Bromotoluene is used in manufacturing pharmaceuticals (especially for nonsteroidal antiinflammatory drugs; Meclofenamic acid, Mefenamic acid) and other organic compounds
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Applications
2-Bromotoluene was used in the synthesis of (±)-isocomene. Suzuki coupling of 2-bromotoluene with phenylboronic acid using palladium nanoparticles supported on alumina-based oxides as catalyst has been reported. 2-Bromotoluene is used in manufacturing pharmaceuticals (especially for nonsteroidal antiinflammatory drugs; Meclofenamic acid, Mefenamic acid) and other organic compounds
Solubility
Soluble in alcohol, ether, acetone, and ethanol. Insoluble in water.
Notes
Hygroscopic. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents. Store at 4°C.
RUO – Research Use Only
Wender PA,; Geoffrey BD. Synthetic studies on arene-olefin cycloadditions. ii. total synthesis of (±)-isocomene.. Tetrahedron . 1981, 37(25), 4445-50.
Berthiol F, et al..Heck reaction of aryl halides with linear or cyclic alkenes catalysed by a tetraphosphine/palladium catalyst . Tetrahedron Lett. 2003, 44(6),1221-25.