Propiolic acid is a reagent used in the preparation of transition metal complexes, haloalkyl propiolates and halopropenoates.
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Applications
Propiolic acid is a reagent used in the preparation of transition metal complexes, haloalkyl propiolates and halopropenoates.
Solubility
Miscible with water, ether, ethanol and chloroform.
Notes
Store in cool place. Incompatible with bases, oxidizing agents and reducing agents.
RUO – Research Use Only
Alkylation of the dilithio-derivative leads to higher 2-alkynoic acids. Reaction with epoxides, partial reduction (Lindlar) of the triple bond and cyclization has been used in the synthesis of unsaturated lactones: Tetrahedron Lett., 2615 (1974); J. Org. Chem., 40, 1610 (1975).
Sun, M.; Sargus, B. A.; Carey, S. J.; Kukolich, S. G. Measurements of deuterium quadrupole coupling in propiolic acid and fluorobenzenes using pulsed-beam Fourier transform microwave spectrometers. J. Chem. Phys 2015, 142 (15), 154306.
Jia, H.; Feng, H.; Sun, Z. Decarboxylative dipropargylation of primary amines with propiolic acids and formaldehyde via metal-free coupling. Tetrahedron 2015, 71 (18), 2724-2728.