Search Thermo Fisher Scientific
Element Search
Structure Search
Thermo Scientific Chemicals
1,3-Dimethoxybenzene, 98%, Thermo Scientific Chemicals
Have Questions?
Change view
Catalog number A13380.36
also known as A13380-36
Price (USD)/ Each
101.65
Online exclusive
113.00 Save 11.35 (10%)
-
Quantity:
500 g
Price (USD)/ Each
101.65
Online exclusive
113.00 Save 11.35 (10%)
1,3-Dimethoxybenzene, 98%, Thermo Scientific Chemicals
Catalog numberA13380.36
Price (USD)/ Each
101.65
Online exclusive
113.00 Save 11.35 (10%)
-
Chemical Identifiers
CAS151-10-0
IUPAC Name1,3-dimethoxybenzene
Molecular FormulaC8H10O2
InChI KeyDPZNOMCNRMUKPS-UHFFFAOYSA-N
SMILESCOC1=CC(OC)=CC=C1
View more
Specifications
Specification Sheet
Specification SheetAppearance (Color)Clear colorless to pale yellow
Assay from Suppliers CofA≥97.5%
FormLiquid
1,3-Dimethoxybenzene is used for the preparation of oxathiane spiroketal donors. It is also used for the formation of pi- and O-ylidic complexes with dichlorocarbene. Further, it acts as a flavoring agent.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
1,3-Dimethoxybenzene is used for the preparation of oxathiane spiroketal donors. It is also used for the formation of pi- and O-ylidic complexes with dichlorocarbene. Further, it acts as a flavoring agent.
Solubility
Miscible with toluene.
Notes
Incompatible with strong oxidizing agents.
1,3-Dimethoxybenzene is used for the preparation of oxathiane spiroketal donors. It is also used for the formation of pi- and O-ylidic complexes with dichlorocarbene. Further, it acts as a flavoring agent.
Solubility
Miscible with toluene.
Notes
Incompatible with strong oxidizing agents.
RUO – Research Use Only
General References:
- Is readily metallated at the 2-position by n-BuLi, giving a lithio-derivative which is doubly-stabilized by oxygen coordination. For reviews, see: Org. React., 8, 258 (1954); 26, 1 (1979). The 2-lithio-derivative undergoes silylation, and the resulting silyl derivative reacts with electrophiles to give various 2-substituted products. For examples, see: Tetrahedron, 49, 10843 (1993):
- Although direct dilithiation with n-BuLi/TMEDA was unsuccessful, a sequence involving monolithiation, silylation and further lithiation at the 4-position gave the 2,4-disilyl derivative in 47% yield: J. Org. Chem., 49, 4657 (1984). For a review of the use of organosilicon intermediates in unusual electrophilic substitutions, see: Synlett, 171 (1993).
- Wang, Q.; Qi, Z.; Xie, F.; Li, X. Lewis Acid-Catalyzed Electrophilic Trifluoromethylthiolation of (Hetero)Arenes. Adv. Synth. Catal. 2015, 357 (2-3), 355-360.
- Tran, P. H.; Hansen, P. E.; Nguyen, H. T.; Le, T. N. Erbium trifluoromethanesulfonate catalyzed Friedel-Crafts acylation using aromatic carboxylic acids as acylating agents under monomode-microwave irradiation. Tetrahedron Lett. 2015, 56 (4), 612-618.