1-Chloro-4-fluorobenzeneis used as a primary and secondary intermediates, organic synthesis. And it is also used to prepare (4'-fluoro-biphenyl-4-yl)-methyl ether by using reagents NaH, Ni (OAc)2, 2,2 '-bipyridyl, KI and solvents benzene, tetrahydrofuran at temperature of 63°C.
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Applications
1-Chloro-4-fluorobenzeneis used as a primary and secondary intermediates, organic synthesis. And it is also used to prepare (4′-fluoro-biphenyl-4-yl)-methyl ether by using reagents NaH, Ni (OAc)2, 2,2 ′-bipyridyl, KI and solvents benzene, tetrahydrofuran at temperature of 63°C.
Solubility
Difficult to mix.
Notes
Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.
RUO – Research Use Only
Lithiation with LDA occurs mainly ortho to F; subsequent carboxylation gives 5-chloro-2-fluorobenzoic acid in moderate yield: Tetrahedron Lett., 33, 7495 (1992). The selectivity is improved by the use of the superbasic combination of n-BuLi and KO-t-Bu, and the yield is increased to 86%: Tetrahedron Lett., 37, 6551 (1996).