L-Isoleucine, 99%
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L-Isoleucine, 99%
Thermo Scientific Chemicals

L-Isoleucine, 99%

L-isoleucine, CAS # 73-32-5, is a branched-chain aliphatic amino acid that is an essential constituent of the diet and is also used in several biological mechanisms, including the biosynthesis of proteins.
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Catalog number A13699.18
also known as A13699-18
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50 g
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Chemical Identifiers
CAS73-32-5
IUPAC Name(2S,3S)-2-amino-3-methylpentanoic acid
Molecular FormulaC6H13NO2
InChI KeyAGPKZVBTJJNPAG-WHFBIAKZSA-N
SMILESCC[C@H](C)[C@H](N)C(O)=O
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White
Assay from Suppliers CofA≥98.5%
FormPowder or crystals or crystalline powder
Optical Rotation+40°± 2° , 20°C
L-Isoleucine acts as an essential amino acid in human. It is used as a flavoring agent and nutritional supplement for foods. It is also used as an antipsychotic. It is employed as a component of proteins. Further, it stimulates immune function and promotes secretion of several hormones. In addition to this, it is used for hemoglobin formation and regulating blood sugar and energy levels.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• L-isoleucine is an essential amino acid that organisms are incapable of synthesizing. It must be ingested in the diet and can be found mainly in meats, fish, cheese, eggs, seeds, and nuts
• L-Isoleucine is an isomer of L-leucine. It is synthesized from threonine and is a branched-chain hydrophobic amino acid

Application

• L-isoleucine is used in several biological mechanisms, including assisting wound healing, detoxifying nitrogenous wastes, stimulating immune function, and promoting hormone secretion
• L-isoleucine shows antipsychotic activity
• It is important for hemoglobin formation and regulating blood sugar and energy levels
• L-isoleucine participates in protein synthesis by binding with transfer RNA (tRNA) in the cell cytoplasm
• This compound also plays an important role as a metabolite for several species, including Saccharomyces cerevisiae, Escherichia coli, plants, algae, and mice
• L-isoleucine can be used as an ingredient for the development of other essential biochemical components in the organism, some of which are used for energy production and stimulants in the upper brain
• It has been used as a supplement of maintenance media (DMEM/F-12) for the culture of primary hepatocytes
• It has been used in capillary feeder assay to determine the consumption of amino acids by Drosophila melanogaster

RUO – Research Use Only

General References:

  1. Han, G.; Hu, X.; Wang, X. Co-production of S-adenosyl-L-methionine and L-isoleucine in Corynebacterium glutamicum. Enzyme Microb. Technol. 2015, 78, 27-33.
  2. Yin, L.; Zhao, J.; Chen, C.; Hu, X.; Wang, X. Enhancing the carbon flux and NADPH supply to increase L-isoleucine production in Corynebacterium glutamicum. Biotechnol. Bioprocess Eng. 2014, 19 (1), 132-142.
  3. Uchizono, s.; Tabuki, Y.; Kawaguchi, N.; Tanimura, T.; Itoh, T. Mated Drosophila melanogaster females consume more amino acids during the dark phase. PLoS One. 2017, 12, (2), e0172886.
  4. Plata-Gómez, A.; Crespo,M.; Arregui, C. Protocol for the assessment of mTOR activity in mouse primary hepatocytes. STAR Protoc. 2021, 2, (4), 100918.