2-Fluorobenzaldehyde, 97%, Thermo Scientific Chemicals
2-Fluorobenzaldehyde, 97%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

2-Fluorobenzaldehyde, 97%, Thermo Scientific Chemicals

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Catalog number A13800.22
also known as A13800-22
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100 g
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2-Fluorobenzaldehyde, 97%, Thermo Scientific Chemicals
Catalog numberA13800.22
Price (USD)/ Each
120.00
-
Add to cart
Chemical Identifiers
CAS446-52-6
IUPAC Name2-fluorobenzaldehyde
Molecular FormulaC7H5FO
InChI KeyZWDVQMVZZYIAHO-UHFFFAOYSA-N
SMILESFC1=CC=CC=C1C=O
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SpecificationsSpecification SheetSpecification Sheet
Free acid (titration)≤2.25%
Refractive Index1.5195-1.5245 @ 20?C
Identification (FTIR)Conforms
FormLiquid
Appearance (Color)Clear colorless to yellow
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2?-(2-Fluorobenzylidene)-2-hydroxybenzohydrazide was synthesized by the reaction of 2-hydroxybenzoylhydrazine with 2-fluorobenzaldehyde in ethanol. Synthesis of n-aryl indolines from 2-fluorobenzaldehyde dimethylhydrazone derivatives which is an approach to preparation of c(aryl)-n(amine) bond atropisomeric amines. The o-dialkylaminobenzaldehydes were conveniently prepared by nucleophilic displacement of the activated fluorine in 2-fluorobenzaldehyde with the required dialkylamine in hot dimethylformamide. N?-(2-Fluorobenzylidene)-2-(quinolin-8-yloxy) acetohydrazide methanol solvate in the reaction of quinolin-8-yloxyacetic acid hydrazide and 2-fluorobenzaldehyde.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
2′-(2-Fluorobenzylidene)-2-hydroxybenzohydrazide was synthesized by the reaction of 2-hydroxybenzoylhydrazine with 2-fluorobenzaldehyde in ethanol. Synthesis of n-aryl indolines from 2-fluorobenzaldehyde dimethylhydrazone derivatives which is an approach to preparation of c(aryl)-n(amine) bond atropisomeric amines. The o-dialkylaminobenzaldehydes were conveniently prepared by nucleophilic displacement of the activated fluorine in 2-fluorobenzaldehyde with the required dialkylamine in hot dimethylformamide. N′-(2-Fluorobenzylidene)-2-(quinolin-8-yloxy) acetohydrazide methanol solvate in the reaction of quinolin-8-yloxyacetic acid hydrazide and 2-fluorobenzaldehyde.

Solubility
Insoluble in water.

Notes
Air Sensitive.Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, reducing agents, air, bases.
RUO – Research Use Only

General References:

  1. Ted Schaefer,; Craig S. Takeuchi. Computations and measurements of the structures and conformations of 2- and 3-fluorobenzaldehyde in the gas and in solution. Canadian Journal of Chemistry,1990, 68(2), 339-345.
  2. Mino, Takashi; Tanaka, Youichi; Hattori, Youtaro; Tanaka, Motoko; Sakamoto, Masami; Fujita, Tsutomu. Synthesis of N-Aryl Indolines from 2-Fluorobenzaldehyde Dimethylhydrazone Derivatives: Approach to Preparation of C(aryl)-N(Amine) Bond Atropisomeric Amines. Letters in Organic Chemistry. 2004, 1 (1), 67-69(3).