Ethyl picolinate is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors which is used in the treatment of diabetes. It is also used as pharmaceutical intermediate.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Ethyl picolinate is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors which is used in the treatment of diabetes. It is also used as pharmaceutical intermediate.
Solubility
Fully miscible in water.
Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
RUO – Research Use Only
David S.Sigman; Catherine T.Jorgensen. Models for metalloenzymes. Zinc (II)-catalyzed transesterification of N-(.beta.-hydroxyethyl)ethylenediamine by p-nitrophenyl picolinate. J. Am. Chem. Soc. 1972, 94,(5), 1724-1730.
Jennifer Lafont; Adolfo Ensuncho; Rosa M.Dominguez; Alexandra Rotinov; Armando Herize; Jairo Quijano; Gabriel Chuchani. Mechanism of elimination of amino acid derivatives in the gas phase. Pyrolysis kinetics of ethyl picolinate, ethyl 1-methylpipecolinate and picolinic acid. Journal of Physical Organic Chemistry. 2003, 16,(1), 84-88.