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1,3-Dichloroacetone, 96%, Thermo Scientific Chemicals
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Catalog number A14149.22
also known as A14149-22
Price (USD)/ Each
139.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
164.00 Save 24.35 (15%)
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Quantity:
100 g
Price (USD)/ Each
139.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
164.00 Save 24.35 (15%)
1,3-Dichloroacetone, 96%, Thermo Scientific Chemicals
Catalog numberA14149.22
Price (USD)/ Each
139.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
164.00 Save 24.35 (15%)
-
Chemical Identifiers
CAS534-07-6
IUPAC Name1,3-dichloropropan-2-one
Molecular FormulaC3H4Cl2O
InChI KeySUNMBRGCANLOEG-UHFFFAOYSA-N
SMILESClCC(=O)CCl
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Specifications
Specification Sheet
Specification SheetAppearance (Color)White to pale brown
FormCrystals or powder or crystalline powder or lumps or fused solid
Assay (GC)≥95.0%
Melting Point (clear melt)35.0-47.0?C
1,3-Dichloroacetone is used in the synthesis of citric acid. It is used as a solvent and as an intermediate in organic synthesis. Further, it serves as an acceptor substrate in the cross-aldol reaction with donor substrates such as acetone, cyclopentanone and cyclohexanone. It is also used in the preparation of an active pharmaceutical ingredient, famotidine.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
1,3-Dichloroacetone is used in the synthesis of citric acid. It is used as a solvent and as an intermediate in organic synthesis. Further, it serves as an acceptor substrate in the cross-aldol reaction with donor substrates such as acetone, cyclopentanone and cyclohexanone. It is also used in the preparation of an active pharmaceutical ingredient, famotidine.
Solubility
Soluble in water, ethanol and diethyl ether.
Notes
Hygroscopic. Store in a cool place. Incompatible with strong oxidizing agents, strong bases and reducing agents.
1,3-Dichloroacetone is used in the synthesis of citric acid. It is used as a solvent and as an intermediate in organic synthesis. Further, it serves as an acceptor substrate in the cross-aldol reaction with donor substrates such as acetone, cyclopentanone and cyclohexanone. It is also used in the preparation of an active pharmaceutical ingredient, famotidine.
Solubility
Soluble in water, ethanol and diethyl ether.
Notes
Hygroscopic. Store in a cool place. Incompatible with strong oxidizing agents, strong bases and reducing agents.
RUO – Research Use Only
General References:
- Successive reaction with a Grignard reagent and Li metal leads to 1-substituted cyclopropanols, which rearrange on thermolysis to ethyl ketones: Synthesis, 647 (1983):
- The cyclization can also be induced by ethyl radicals, generated from ethylmagnesium bromide and FeCl3. This method is applicable only to 1-arylcyclopropanols: J. Org. Chem., 29, 2813 (1964); 43, 3602 (1978); Org. Synth. Coll., 5, 1058 (1973).
- Formation of the acetal followed by treatment with NaNH2 provides a route to cyclopropenones: Tetrahedron, 48, 2045 (1992).
- Serrano, M.; Silva, M.; Gallego, M. Determination of 14 haloketones in treated water using solid-phase microextraction and gas chromatography-mass spectrometry. J. Chromatogr. A 2015, 1407, 208-215.
- Deng, J.; Chen, K.; Yao, Z.; Lin, J.; Wei, D. Efficient synthesis of optically active halogenated aryl alcohols at high substrate load using a recombinant carbonyl reductase from Gluconobacter oxydans. J. Mol. Catal. B: Enzym. 2015, 118, 1-7.