It is used in the Mitsunobu reaction of methyl salicylate coupling of sterically hindered substrates.
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Applications
It is used in the Mitsunobu reaction of methyl salicylate coupling of sterically hindered substrates.
Solubility
Soluble in water at (20°C 40 g/L), alcohol, and ether. Solubility in methanol is almost transparent.
Notes
Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
RUO – Research Use Only
General References:
- Sudhakar Bhandaru, et al. Synthesis of a C14',15' dihydro derivative of the south hexacyclic steroid unit of cephalostatin 1. Part I : regiospecific Rh[II]-mediated intermolecular oxygen alkylation of a primary neopentyl alcohol.Tetrahedron Lett.,1995,36(46), 8347-8350.
- J. D. Slagle, et al. Mechanism of the triphenylphosphine-tetrachloromethane-alcohol reaction: pericyclic or clustered ion pairs?J. Org. Chem.,1981,46(17), 3526-3530.
- A method has been described for conversion to the iodide using a combination of methyl iodide and triphenyl phosphite: Org. Synth. Coll., 6, 830 (1988).