Search Thermo Fisher Scientific
Element Search
Structure Search
Thermo Scientific Chemicals
4-Hydroxycoumarin, 98+%, Thermo Scientific Chemicals
Have Questions?
Change view
Catalog number A14394.0E
also known as A14394-0E
Price (USD)/ Each
666.00
-
Quantity:
2500 g
Price (USD)/ Each
666.00
4-Hydroxycoumarin, 98+%, Thermo Scientific Chemicals
Catalog numberA14394.0E
Price (USD)/ Each
666.00
-
Chemical Identifiers
CAS1076-38-6
IUPAC Name2-hydroxy-4H-chromen-4-one
Molecular FormulaC9H6O3
InChI KeyOWBBAPRUYLEWRR-UHFFFAOYSA-N
SMILESOC1=CC(=O)C2=CC=CC=C2O1
View more
Specifications
Specification Sheet
Specification SheetAssay (HPLC)≥98.0%
FormCrystals or powder or crystalline powder
Appearance (Color)White to pale cream
Assay (Aqueous acid-base Titration)≥98.0 to ≤102.0%
4-Hydroxycoumarin is involved in annulation reactions, due to the relatively high acidity of the C-H bond at the 3-position: a three-component reaction with isocyanides and dialkyl acetylene dicarboxylates affords annulated 4H-pyrans.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
4-Hydroxycoumarin is involved in annulation reactions, due to the relatively high acidity of the C-H bond at the 3-position: a three-component reaction with isocyanides and dialkyl acetylene dicarboxylates affords annulated 4H-pyrans.
Solubility
Soluble in ethanol and dimethyl formamide. Insoluble in water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents and strong bases.
4-Hydroxycoumarin is involved in annulation reactions, due to the relatively high acidity of the C-H bond at the 3-position: a three-component reaction with isocyanides and dialkyl acetylene dicarboxylates affords annulated 4H-pyrans.
Solubility
Soluble in ethanol and dimethyl formamide. Insoluble in water.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents and strong bases.
RUO – Research Use Only
General References:
- M. R. HADLER.; R. S. SHADBOLT. Novel 4-hydroxycoumarin anticoagulants active against resistant rats. Nature. 1975, 253 275 - 277.
- A. M. El-Agrody.; M. S. Abd El-Latif.; N. A. El-Hady.;A. H. Fakery.; A. H. Bedair. Heteroaromatization with 4-Hydroxycoumarin Part II: Synthesis of Some New Pyrano[2,3-d]pyrimidines, [1,2,4]triazolo[1,5-c]pyrimidines and Pyrimido[1,6-b]-[1,2,4]triazine Derivatives. Molecules. 2001, 6 (6), 519-527.
- Like 4-Hydroxy-6-methyl-2-pyrone, L11457, can participate in annulation reactions, due to the relatively high acidity of the C-H bond at the 3-position: a three-component reaction with isocyanides and dialkyl acetylene dicarboxylates affords annulated 4H-pyrans: Tetrahedron, 62, 3016 (2006). For reaction scheme, see: tert-Butyl isocyanide, L19747.