Search Thermo Fisher Scientific
Element Search
Structure Search
Thermo Scientific Chemicals
4,4'-Dimethoxybenzhydrol, 98+%, Thermo Scientific Chemicals
Have Questions?
Change view
Catalog number A14604.18
also known as A14604-18
Price (USD)/ Each
277.00
-
Quantity:
50 g
Price (USD)/ Each
277.00
4,4'-Dimethoxybenzhydrol, 98+%, Thermo Scientific Chemicals
Catalog numberA14604.18
Price (USD)/ Each
277.00
-
Chemical Identifiers
CAS728-87-0
Specifications
Specification Sheet
Specification SheetAppearance (Color)White
Melting Point (clear melt)67.0-73.0?C
Identification (FTIR)Conforms
FormPowder
Assay (HPLC)≥98.0%
4,4?-Dimethoxybenzhydrol was used to study the kinetics and mechanism of oxidation of substituted benzhydrols to corresponding benzophenones in the presence of Hg(OAc)2 by N-bromosuccinimide. It is useful in the protection of glutamine and asparagine residues in peptide synthesis, reagent for the N-protection of amides.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
4,4′-Dimethoxybenzhydrol was used to study the kinetics and mechanism of oxidation of substituted benzhydrols to corresponding benzophenones in the presence of Hg(OAc)2 by N-bromosuccinimide. It is useful in the protection of glutamine and asparagine residues in peptide synthesis, reagent for the N-protection of amides.
Solubility
Soluble in water (0.44 g/L @ 25°C), methanol (0.1 g/mL).
Notes
Store in cool, dry conditions in a well sealed container. Store away from oxidizing agents.
4,4′-Dimethoxybenzhydrol was used to study the kinetics and mechanism of oxidation of substituted benzhydrols to corresponding benzophenones in the presence of Hg(OAc)2 by N-bromosuccinimide. It is useful in the protection of glutamine and asparagine residues in peptide synthesis, reagent for the N-protection of amides.
Solubility
Soluble in water (0.44 g/L @ 25°C), methanol (0.1 g/mL).
Notes
Store in cool, dry conditions in a well sealed container. Store away from oxidizing agents.
RUO – Research Use Only
General References:
- B. L. Hiran; R. K. Malkani; N. Rathore. Kinetics and mechanism of oxidation of some substituted benzhydrols by N-bromosuccinimide. Kinetics and Catalysis. 1992, 46 (3), 334-339.
- C Henneuse; T Boxus; L Tesolin; G Pantano. One-Step Hydroxy Substitution of 4, 4'-Dimethoxybenzhydrol with Amides, Lactams, Carbamates, Ureas and Anilines. Synthesis. 1996, 1996 (4), 495-501.
- Reagent for the N-protection of amides, useful in the protection of glutamine and asparagine residues in peptide synthesis. Substitution of the OH group with amide and a variety of other N functionalities occurs readily in AcOH with H2SO4 catalysis: Chem. Ber., 103, 2041 (1970); Synthesis, 495 (1996). Deprotection occurs in TFA.