2-Bromothiazole, 99%, Thermo Scientific Chemicals

General References:

1. Henri Jean Marie Dou.; Roger Gallo.; Parina Hassanaly.; Jacques Metzger. Behavior and stability of catalysts in bi- and triphase transfer catalysis. J. Org. Chem . 1977, 42, (26), 4275-4276.AO Pittet .; DE Hruza. Comparative study of flavor properties of thiazole derivatives. Journal of Agricultural and Food Chemistry. 1974, 22, (2), 264-269.
2. 2-Lithiothiazole can be obtained by direct lithiation of thiazole or, more conveniently, by exchange with 2-bromothiazole using n-BuLi: J. Org. Chem., 53, 1748 (1988). It behaves as a valuable formyl anion equivalent, and as such has been applied, mainly by Dondoni's group, in the syntheses of a variety of products; see, e.g.: Tetrahedron Lett., 34, 7319, 7323, 7327 (1993). See also 2-(Trimethyl silyl) thiazole, B21903. Reaction of 2-lithiothiazole with nitrones gives ɑ-aminoaldehydes: Tetrahedron Lett., 33, 4221 (1992); stereocontrolled addition to C-galacto-pyranosylnitrone has been used in syntheses of destomic acid, a component of the antibiotics destomycin and hygromycin, and of lincosamine, the sugar component of the anticancer antibiotic lincomycin: Synlett, 78 (1993). For applications of 2-lithiothiazole in the synthesis of the aza-sugar (+)-galactostsin, see: J. Org. Chem., 60, 4749 (1995). The Thiazole Aldehyde Synthesis has been reviewed by Dondoni: Synthesis, 1681 (1998).