3-Bromobenzyl bromide was used in the synthesis of, 1,7-di(3-bromobenzyl)cyclen and substituted 8-arylquinoline, phosphodiesterase 4 (PDE4) inhibitors.
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Applications
3-Bromobenzyl bromide was used in the synthesis of, 1,7-di(3-bromobenzyl)cyclen and substituted 8-arylquinoline, phosphodiesterase 4 (PDE4) inhibitors.
Solubility
Insoluble in water.
Notes
Store in cool, dry place in tightly closed container. Store away from oxidizing agent.
RUO – Research Use Only
General References:
- Averin AD, et al. Synthesis of a new family of bi-and polycyclic compounds via Pd-catalyzed amination of 1, 7-di (3-bromobenzyl) cyclen. Tetrahedron Lett, 2008, 49(24), 3950-54.
- Dwight Macdonald et. al. Discovery of a substituted 8-arylquinoline series of PDE4 inhibitors: structure-activity relationship, optimization, and identification of a highly potent, well tolerated, PDE4 inhibitor. Bioorganic & Medicinal Chemistry Letters, 2005, 15(23), 5241-5246.