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6,7-Dihydroxycoumarin, 98+%, Thermo Scientific Chemicals
Catalog number: A15393.03
1 g, Each
Thermo Scientific Chemicals
6,7-Dihydroxycoumarin, 98+%, Thermo Scientific Chemicals
Catalog number: A15393.03
1 g, Each
Quantity
Catalog number: A15393.03
also known as A15393-03
Price (USD)
75.50
Each
Quantity
-
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Chemical Identifiers
CAS
305-01-1
IUPAC Name
6,7-dihydroxy-2H-chromen-2-one
Molecular Formula
C9H6O4
InChI Key
ILEDWLMCKZNDJK-UHFFFAOYSA-N
SMILES
OC1=C(O)C=C2C=CC(=O)OC2=C1
Specifications
Specification SheetAppearance (Color)
Cream to yellow to pale brown
Form
Crystals or powder or crystalline powder
Assay (HPLC)
≥98.0%
Description
In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.
Solubility
Soluble in DMSO, DMF, diluted alkalies with blue fluorescence, and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid, and hot ethanol.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents.
In the presence of esculetin and HA14-1 (sc-205911) expression of the death receptor 4 (DR4) has been observed to be upregulated and extracellular-regulated kinase (ERK) to be activated. Other studies suggest that esculetin upregulates death receptor 5 (DR5) protein expression, and enhances TRAIL-induced apoptosis. It also inhibits the activity of 12-LO (12-lipoxygenase), and decreases leukotriene biosynthesis during 5-LO inhibition.
Solubility
Soluble in DMSO, DMF, diluted alkalies with blue fluorescence, and acetone. Slightly soluble in water. Insoluble in ether. Moderately soluble in Glacial acetic acid, and hot ethanol.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agents.
RUO – Research Use Only
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