4-Hydroxy-3,5-dimethoxycinnamic acid is a commonly used matrix in MALDI mass spectrometry. It is a useful matrix for a wide variety of peptides and proteins. It serves well as a matrix for MALDI due to its ability to absorb laser radiation and to also donate protons (H+) to the analyte of interest.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
4-Hydroxy-3,5-dimethoxycinnamic acid is a commonly used matrix in MALDI mass spectrometry. It is a useful matrix for a wide variety of peptides and proteins. It serves well as a matrix for MALDI due to its ability to absorb laser radiation and to also donate protons (H+) to the analyte of interest.
Solubility
Soluble in methanol, ethanol and dimethyl sulfoxide.
Notes
Store in cool dry place in tightly closed container. With good ventilation. Store away from oxidizing agent.
RUO – Research Use Only
General References:
- Ronald C. Beavis; and Brian T. Chait. Matrix-assisted laser-desorption mass spectrometry using 355 nm radiation. Rapid Communications in Mass Spectrometry. 1989, 3 (12), 436-439.
- Ronald C. Beavis; and Brian T. Chait. Cinnamic acid derivatives as matrices for ultraviolet laser desorption mass spectrometry of proteins. Rapid Communications in Mass Spectrometry. 1989, 3 (12), 432-435.