4-tert-butylphenol on condensation with formaldehyde gives calix[5]arene which is used in enzyme mimetics.
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Applications
4-tert-butylphenol on condensation with formaldehyde gives calix[5]arene which is used in enzyme mimetics.
Solubility
Soluble in water. [8.7 g/L (20°C)]
Notes
Store at room temperature. Keep away from oxidizing agents and acids.
RUO – Research Use Only
C. David Gutsche.; Balram Dhawan.; Kwang Hyun No.; Ramamurthi Muthukrishnan. Calixarenes. 4. The synthesis, characterization, and properties of the calixarenes from p-tert-butylphenol. J. Am. Chem. Soc. 1981, 103 (13),3782-3792 .
The acid-catalyzed removal of t-butyl groups from phenols (reverse Friedel-Crafts reaction), can be brought about without the need for t-butyl acceptors by using aluminum chloride as catalyst in dichloromethane at ambient temperature: Synth. Commun., 18, 1783 (1988).