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cis-Aconitic anhydride, 98%, Thermo Scientific Chemicals
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Catalog number A16006.03
also known as A16006-03
Price (USD)/ Each
56.10
-
Quantity:
1 g
Price (USD)/ Each
56.10
cis-Aconitic anhydride, 98%, Thermo Scientific Chemicals
Catalog numberA16006.03
Price (USD)/ Each
56.10
-
Chemical Identifiers
CAS6318-55-4
IUPAC Name2-(2,5-dioxo-2,5-dihydrofuran-3-yl)acetic acid
Molecular FormulaC6H4O5
InChI KeyGVJRTUUUJYMTNQ-UHFFFAOYSA-N
SMILESOC(=O)CC1=CC(=O)OC1=O
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Specifications
Specification Sheet
Specification SheetAppearance (Color)White to cream to pale brown
FormPowder or crystalline powder
Assay (Aqueous acid-base Titration)≥97.5 to ≤102.5%
Infrared spectrumConforms
Melting Point (clear melt)72-79?C
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cis-Aconitic anhydride is used in the preparation of poly(amino acid)-containing copolymers with gradient pH-sensitive side groups initiated by the amino groups in methoxy poly(ethylene glycol)-block-poly(L-lysine). It is also involved in the preparation of pH-sensitive anti-tumor prodrug nanoparticles by conjugation with D-alfa-tocopheryl polyethylene glycol 1000 succinate (TPGS).
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
cis-Aconitic anhydride is used in the preparation of poly(amino acid)-containing copolymers with gradient pH-sensitive side groups initiated by the amino groups in methoxy poly(ethylene glycol)-block-poly(L-lysine). It is also involved in the preparation of pH-sensitive anti-tumor prodrug nanoparticles by conjugation with D-alfa-tocopheryl polyethylene glycol 1000 succinate (TPGS).
Notes
Moisture sensitive. Incompatible with strong acids, strong oxidizing agents and strong bases. Store in a cool place.
cis-Aconitic anhydride is used in the preparation of poly(amino acid)-containing copolymers with gradient pH-sensitive side groups initiated by the amino groups in methoxy poly(ethylene glycol)-block-poly(L-lysine). It is also involved in the preparation of pH-sensitive anti-tumor prodrug nanoparticles by conjugation with D-alfa-tocopheryl polyethylene glycol 1000 succinate (TPGS).
Notes
Moisture sensitive. Incompatible with strong acids, strong oxidizing agents and strong bases. Store in a cool place.
RUO – Research Use Only
General References:
- Sun, D.; Ding, J.; Xiao, C.; Chen, J.; Zhuang, X.; Chen, X. pH-Responsive Reversible PEGylation Improves Performance of Antineoplastic Agent. Adv. Healthcare Mater. 2015, 4 (6), 844-855.
- Chen, J.; Ding, J.; Zhang, Y.; Xiao, C.; Zhuang, X.; Chen, X. Polyion complex micelles with gradient pH-sensitivity for adjustable intracellular drug delivery. Polym. Chem. 2015, 6 (3), 397-405.