Methyl Trifluoroacetate, 98+%, Thermo Scientific Chemicals

Useful reagent for trifluoroacetylation of amines under mild conditions. In the presence of 1,1,3,3-Tetramethyl­guanidine, has also been used for the N-acylation of amino acids. It is used as an intermediate in the synthesis of pharmaceutical and agricultural chemicals. The chemical reactions usually involve nucleophilic substitution of the ester and are useful for the preparation of trifluoroacylated compounds.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Useful reagent for trifluoroacetylation of amines under mild conditions. In the presence of 1,1,3,3-Tetramethyl­guanidine, has also been used for the N-acylation of amino acids. It is used as an intermediate in the synthesis of pharmaceutical and agricultural chemicals. The chemical reactions usually involve nucleophilic substitution of the ester and are useful for the preparation of trifluoroacylated compounds.

Solubility
Not miscible or difficult to mix in water.

Notes
Moisture sensitive. Store away from strong bases, water/moisture and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Protect from humidity.