Search Thermo Fisher Scientific
Element Search
Structure Search
Thermo Scientific Chemicals
Bilirubin 97%, Thermo Scientific Chemicals
Bilirubin 97%, CAS # 635-65-4, is a tetrapyrroliccompound found in bile that is a product of heme catabolism.
Have Questions?
Change view
Catalog number A17522.14
also known as A17522-14
Price (USD)Contact Us
-
Quantity:
25 g
Chemical Identifiers
CAS635-65-4
IUPAC Name3-(2-{[3-(2-carboxyethyl)-5-{[(2Z)-4-ethenyl-3-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-ylidene]methyl}-4-methyl-1H-pyrrol-2-yl]methyl}-5-{[(2Z)-3-ethenyl-4-methyl-5-oxo-2,5-dihydro-1H-pyrrol-2-ylidene]methyl}-4-methyl-1H-pyrrol-3-yl)propanoic acid
Molecular FormulaC33H36N4O6
InChI KeyBPYKTIZUTYGOLE-IFADSCNNSA-N
SMILESCC1=C(C=C)\C(NC1=O)=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(CCC(O)=O)C(C)=C(N2)\C=C2/NC(=O)C(C=C)=C2C)N1
View more
Specifications
Specification Sheet
Specification SheetAppearance (Color)Red to orange to brown
Assay from Supplier's CofA≥96.0% (U.S. sourced material)
Loss on Drying≤ 2.0% (200°C/constant wt.)
FormPowder
CommentMaterial sourced in the U.S. and in other countries
View more
Bilirubin is widely utilized to monitor the liver function and their disease, such as hepatitis or cirrhosis; or the effects of medicines which are damage the liver. It acts as a pigment in certain algae to capture light energy. Its double bonds are isomerizes in the presence of light, which is employed in phototherapy of jaundiced newborns babies. It is used to detect the blocking in bile ducts.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Bilirubin is a degradation product of heme following the activity of heme oxidase. Bilirubin is produced in the reticuloendothelial system and conjugated in the liver. It appears as an orange-yellow pigment that is secreted in the bile
- High levels of unconjugated bilirubin can result in jaundice, a condition of the yellowing of skin and eyes. This can be toxic and may be a sign of severe liver disease
- Bilirubin has been seen to have functions including cell signaling, metabolism modulation, and immune regulation
- It has protective antioxidant activity at moderate levels
Application
- Bilirubin is widely used in studies of liver function and disease, such as hepatitis or cirrhosis
- As an antioxidant, bilirubin has been studied in protection against H2O2-mediated cell death
- It can be used as a scavenger of reactive oxygen species (ROS) or as an inhibitor of NADPH oxidase
RUO – Research Use Only
General References:
- Hinds TD Jr, Stec DE. Bilirubin, a Cardiometabolic Signaling Molecule. Hypertension. 2018 Oct;72(4):788-795. doi: 10.1161/HYPERTENSIONAHA.118.11130. Erratum in: Hypertension. 2018 Dec;72(6):e95. PMID: 30354722; PMCID: PMC6205727.
- Vítek L, Tiribelli C. Bilirubin: The yellow hormone? J Hepatol. 2021 Dec;75(6):1485-1490. doi: 10.1016/j.jhep.2021.06.010. Epub 2021 Jun 18. PMID: 34153399.