1-Chloro-2-iodobenzene is used as a precursor and involved in the preparation of 2,2'-dichloro-biphenyl. It is also used to prepare N,N-diaryl-o-phenylenediamines and 4(5)-(2-chlorophenyl)-1H-imidazole. It reacts with lanthanum metal in the presence of trimethylchlorosilane to prepare 1-chloro-2-trimethylsilylbenzene.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
1-Chloro-2-iodobenzene is used as a precursor and involved in the preparation of 2,2′-dichloro-biphenyl. It is also used to prepare N,N-diaryl-o-phenylenediamines and 4(5)-(2-chlorophenyl)-1H-imidazole. It reacts with lanthanum metal in the presence of trimethylchlorosilane to prepare 1-chloro-2-trimethylsilylbenzene.
Solubility
Miscible with most common organic solvents. Immiscible with water.
Notes
Light sensitive. Incompatible with strong oxidizing agents, strong acids and bases. Store in a cool place. Keep the container tightly closed.
RUO – Research Use Only
General References:
- Xu, Z.; Yang, T.; Lin, X.; Elliott, J. D.; Ren, F. A mild and efficient carboxylate-directed C-H arylation of aryl carboxylic acids with iodobenzenes in water. Tetrahedron Lett. 2015, 56 (2), 475-477.
- Rotta-Loria, N. L.; Borzenko, A.; Alsabeh, P. G.; Lavery, C. B.; Stradiotto, M. Utilizing Mor-DalPhos/Palladium-Catalyzed Monoarylation in the Multicomponent One-Pot Synthesis of Indoles. Adv. Synth. Catal. 2015, 357 (1), 100-106.