1-Acetylpiperazine may be used in the synthesis of series of 7-alkoxyl substituted indolizinoquinoline-5,12-dione derivatives and 2-substituted-N-(naphth-1-ylmethyl)-pyrimidin-4-amines and 2-substituted-N-benzhydrylpyrimidin-4-amines.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
1-Acetylpiperazine may be used in the synthesis of series of 7-alkoxyl substituted indolizinoquinoline-5,12-dione derivatives and 2-substituted-N-(naphth-1-ylmethyl)-pyrimidin-4-amines and 2-substituted-N-benzhydrylpyrimidin-4-amines.
Solubility
Soluble in water 210 g/L (20°C).
Notes
Hygroscopic. Store under inert gas. Store away from oxidizing agents, moisture.
RUO – Research Use Only
General References:
- Zu-Ping Wu; Xi-Wei Wu; Ting Shen; Yan-Ping Li; Xi Cheng; Lian-Quan Gu; Zhi-Shu Huang; Lin-Kun An. Synthesis and acetylcholinesterase and butyrylcholinesterase inhibitory activities of 7-alkoxyl substituted indolizinoquinoline-5,12-dione derivatives. Archiv der Pharmazie (Weinheim). 2012, 345 (3), 175-184.
- Tarek Mohamed; Jacky C K Yeung; Praveen P N Rao; Tarek Mohamed; Jacky C K Yeung; Praveen P N Rao; Tarek Mohamed; Jacky C.K. Yeung; Praveen P.N. Rao. Development of 2-substituted-N-(naphth-1-ylmethyl) and N-benzhydrylpyrimidin-4-amines as dual cholinesterase and Aβ-aggregation inhibitors: Synthesis and biological evaluation.Bioorganic & Medicinal Chemistry Letters. 2011, 21 (19), 5881-5887.