Trichloroacetyl chloride is used in the preparation of dihydro-1H-benzindoles. It is also used in the synthesis of 3-alkylbenzoxazolones It is used in the manufacture of pharmaceuticals and plant protection compounds. It is used for manufacturing the esters and anhydrides of trichloroacetic acid. It is used in the manufacture of pharmaceuticals and organic synthesis intermediate.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Trichloroacetyl chloride is used in the preparation of dihydro-1H-benzindoles. It is also used in the synthesis of 3-alkylbenzoxazolones It is used in the manufacture of pharmaceuticals and plant protection compounds. It is used for manufacturing the esters and anhydrides of trichloroacetic acid. It is used in the manufacture of pharmaceuticals and organic synthesis intermediate.
Solubility
Reacts violently with water.
Notes
Moisture sensitive. Store away from oxidizing agents, bases, alcohols, amines and water/moisture. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.
RUO – Research Use Only
Ram N Ram and Vineet Kumar Soni. Synthesis of 3-alkylbenzoxazolones from N-alkyl-N-arylhydroxylamines by contiguous O-trichloroacetylation, trichloroacetoxy ortho-shift, and cyclization sequence.J Org Chem.201378(23), 11935-11947.
Gustavo P Silveira and Joseph P Marino. Enantioselective synthesis of dihydro-1H-benzindoles.J. Org. Chem.201378(7), 3379-3383.