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Tolbutamide, 98%, Thermo Scientific Chemicals
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Catalog number B21698.18
also known as B21698-18
Price (USD)/ Each
182.00
-
Quantity:
50 g
Price (USD)/ Each
182.00
Tolbutamide, 98%, Thermo Scientific Chemicals
Catalog numberB21698.18
Price (USD)/ Each
182.00
-
Chemical Identifiers
CAS64-77-7
IUPAC Name3-butyl-1-(4-methylbenzenesulfonyl)urea
Molecular FormulaC12H18N2O3S
InChI KeyJLRGJRBPOGGCBT-UHFFFAOYSA-N
SMILESCCCCNC(=O)NS(=O)(=O)C1=CC=C(C)C=C1
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Specifications
Specification Sheet
Specification SheetAssay (Aqueous acid-base Titration)≥97.5 to ≤102.5% (UK-sourced material)
Assay (HPLC)≥97.5%
CommentMaterial sourced in UK and US
Assay from Supplier's CofA≥97.5% (US-sourced material)
Melting Point (clear melt)126-130°C
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Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.
Solubility
Soluble in chloroform.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.
Tolbutamide, have been used in a cDNA microarray assay to probe changes in gene expression in HepG2 cells upon their administration. It has been utilized to counteract insulin activity in a patch-clamp investigation of ATP sensitive K+ channels in mouse pancreatic β-cells. The activity of various biotransformation enzymes in cultured primary rat proximal tubular cells in the presence of tolbutamide and other compounds has been studied.
Solubility
Soluble in chloroform.
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.
RUO – Research Use Only
General References:
- Sullivan-Klose,et.al. The role of the CFP2C9-Leu 359 allelic variant in the tolbutamide polymorphism. Pharmacogenetics. 1996, 6 (4), 2702-2705.
- Michael Perley, MD; and David M Kipnis, MD. Plasma Insulin Responses to Glucose and Tolbutamide of Normal Weight and Obese Diabetic and Nondiabetic Subjects. Diabetes, 1966, 15(12), 867-874.