Hydroxylamine is a reactant used for the preparation of hydroxyaminoguanidines which are anti-cancer agents, carboxamide derivatives of ofloxacin and human immunodeficiency virus (HIV) integrase inhibitors. It reacts with chlorosulfonic acid to give hydroxylamine-O-sulfonic acid, a useful reagent in the synthesis of caprolactam. It is commonly used as a reducing agent in myriad of organic and inorganic reactions. It acts as an antioxidant for fatty acids. It is widely used to prepare oximes, an important functional group.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Hydroxylamine is a reactant used for the preparation of hydroxyaminoguanidines which are anti-cancer agents, carboxamide derivatives of ofloxacin and human immunodeficiency virus (HIV) integrase inhibitors. It reacts with chlorosulfonic acid to give hydroxylamine-O-sulfonic acid, a useful reagent in the synthesis of caprolactam. It is commonly used as a reducing agent in myriad of organic and inorganic reactions. It acts as an antioxidant for fatty acids. It is widely used to prepare oximes, an important functional group.
Solubility
Miscible with water, liquid ammonia and methanol. Slightly miscible with ether, benzene, carbon disulfide and chloroform.
Notes
It can violently decompose at elevated temperatures. May be shock-sensitive if dry. Do not heat over 500C. Incompatible with bases, oxidizing agents, nitrates, nitrites, heavy metals, rubber, metals, epoxides and polyester.
RUO – Research Use Only
General References:
- Heil, J.; Liu, S.; Vereecken, H.; Brüggemann, N. Abiotic nitrous oxide production from hydroxylamine in soils and their dependence on soil properties. Soil Biol. Biochem. 2015, 84, 107-115.
- Alibeik, M. A.; Moaddeli, A. Multi-component one-pot reaction of aldehyde, hydroxylamine and sodium azide catalyzed by Cu-MCM-41 nanoparticles: a novel method for the synthesis of 5-substituted 1 H-tetrazole derivatives. New J. Chem. 2015, 39 (3), 2116-2122.