Dibenzyl N,N-diisopropylphosphoramidite may be used for the preparation of phosphopeptides. It is used for the synthesis of a GDP (guanosine diphosphate) analog, SML-8-73-1. It is useful for nucleotide coupling.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Dibenzyl N,N-diisopropylphosphoramidite may be used for the preparation of phosphopeptides. It is used for the synthesis of a GDP (guanosine diphosphate) analog, SML-8-73-1. It is useful for nucleotide coupling.
Solubility
Soluble in chloroform.
Notes
Moisture sensitive. Store under inert gas. Store at 0°C. Incompatible with oxidizing agents, water/ moisture.
RUO – Research Use Only
D L Clemm; L Sherman; V Boonyaratanakornkit; W T Schrader; N L Weigel; D P Edwards. Differential hormone-dependent phosphorylation of progesterone receptor A and B forms revealed by a phosphoserine site-specific monoclonal antibody. Molecular Endocrinology. 2000, 14 (1), 52-65.
Sang Min Lim; Kenneth D Westover; Scott B Ficarro; Rane A Harrison; Hwan Geun Choi; Michael E Pacold; Martin Carrasco; John Hunter; Nam Doo Kim; Ting Xie; Taebo Sim, Pasi A Jänne; Matthew Meyerson; Jarrod A Marto; John R Engen; Nathanael S Gray. Therapeutic targeting of oncogenic K-Ras by a covalent catalytic site inhibitor. Angewandte Chemie. 2014, 53 (1), 199-204.
Phosphitylating agent which reacts with an alcohol under mild conditions. Subsequent oxidation, e.g. with hydrogen peroxide, followed by hydrogenolysis of the benzyl groups, affords the alkyl phosphate: Tetrahedron Lett., 29, 979 (1988).