3-Methoxybenzoyl chloride is used in the synthesis of 2-arylbenzofuran-based molecules that act against Alzheimer’s disease, combating symptoms. In addition, it aids in the optimization of dihydropyrrolopyrimidine inhibitors against PI3K (phosphoinositide 3-kinase) resulting in tumor growth inhibition.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Solubility
Soluble in chloroform. Reacts with water.
Notes
Moisture Sensitive. Store under dry inert gas. Store away from moisture, strong bases and oxidizing agents. Protect from humidity and water.
RUO – Research Use Only
Stefano Rizzoa; Andrea Tarozzi; Manuela Bartolini; Gregory Da Costa; Alessandra Bisi; Silvia Gobbi; Federica Belluti; Alessia Ligresti; Marco Allarà; Jean-Pierre Monti; Vincenza Andrisano; Vincenzo Di Marzo; Patrizia Hrelia; Angela Rampa. 2-Arylbenzofuran-based molecules as multipotent Alzheimer’s disease modifying agents. European Journal of Medicinal Chemistry. 2012, 58, 519-532.
Hatsuo Kawada; Hirosato Ebiike; Masao Tsukazaki; Mitsuaki Nakamura; Kenji Morikami; Kiyoshi Yoshinari; Miyuki Yoshida; Kotaro Ogawa; Nobuo Shimma; Takuo Tsukuda; Jun Ohwada. Bioorganic & Medicinal Chemistry Letters. 2013, 23, 673-678.