Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent. It is also used as an inhibitor of bacterial DNA gyrase. It plays an important role in the treatment of urinary tract infections caused by susceptible gram-negative microorganisms, including the majority of E. Coli, Enterobacter species, Klebsiella species and Proteus species.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent. It is also used as an inhibitor of bacterial DNA gyrase. It plays an important role in the treatment of urinary tract infections caused by susceptible gram-negative microorganisms, including the majority of E. Coli, Enterobacter species, Klebsiella species and Proteus species.
Solubility
Soluble in diethyl ether, acetone, methylene chloride, chloroform and methanol. Insoluble in water.
Notes
Light sensitive and air sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.
RUO – Research Use Only
Chintagari, S.; Hung, Y. C.; Hamanaka, D. Resistance of various STEC strains and serogroups to UV radiation and effect of nalidixic acid adaptation. Food Control 2015, 50, 313-319.
Dwivedi, G. R.; Maurya, A.; Yadav, D. K.; Khan, F.; Darokar, M. P.; Srivastava, S. K. Drug Resistance Reversal Potential of Ursolic Acid Derivatives against Nalidixic Acid- and Multidrug-resistant Escherichia coli. Chem. Biol. Drug Des. 2015, 86 (3), 272-283.