Nalidixic acid, 99%, Thermo Scientific Chemicals
Nalidixic acid, 99%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Nalidixic acid, 99%, Thermo Scientific Chemicals

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Catalog number B25096.22
also known as B25096-22
Price (USD)/ Each
268.65
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298.00 
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Quantity:
100 g
Request bulk or custom format
Price (USD)/ Each
268.65
Online exclusive
298.00 
Save 29.35 (10%)
Add to cart
Nalidixic acid, 99%, Thermo Scientific Chemicals
Catalog numberB25096.22
Price (USD)/ Each
268.65
Online exclusive
298.00 
Save 29.35 (10%)
-
Add to cart
Chemical Identifiers
CAS389-08-2
IUPAC Name1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
Molecular FormulaC12H12N2O3
InChI KeyMHWLWQUZZRMNGJ-UHFFFAOYSA-N
SMILESCCN1C=C(C(O)=O)C(=O)C2=CC=C(C)N=C12
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SpecificationsSpecification SheetSpecification Sheet
Melting Point (clear melt)224.0-233.0?C
Identification (FTIR)Conforms
Appearance (Color)White to pale cream to pale yellow
FormPowder
Assay (Aqueous acid-base Titration)≥98.5 to ≤101.5%
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Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent. It is also used as an inhibitor of bacterial DNA gyrase. It plays an important role in the treatment of urinary tract infections caused by susceptible gram-negative microorganisms, including the majority of E. Coli, Enterobacter species, Klebsiella species and Proteus species.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Nalidixic acid is a synthetic 1,8-naphthyridine antimicrobial agent. It is also used as an inhibitor of bacterial DNA gyrase. It plays an important role in the treatment of urinary tract infections caused by susceptible gram-negative microorganisms, including the majority of E. Coli, Enterobacter species, Klebsiella species and Proteus species.

Solubility
Soluble in diethyl ether, acetone, methylene chloride, chloroform and methanol. Insoluble in water.

Notes
Light sensitive and air sensitive. Store in a cool place. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.
WARNING: Cancer – www.P65Warnings.ca.gov
RUO – Research Use Only

General References:

  1. Chintagari, S.; Hung, Y. C.; Hamanaka, D. Resistance of various STEC strains and serogroups to UV radiation and effect of nalidixic acid adaptation. Food Control 2015, 50, 313-319.
  2. Dwivedi, G. R.; Maurya, A.; Yadav, D. K.; Khan, F.; Darokar, M. P.; Srivastava, S. K. Drug Resistance Reversal Potential of Ursolic Acid Derivatives against Nalidixic Acid- and Multidrug-resistant Escherichia coli. Chem. Biol. Drug Des. 2015, 86 (3), 272-283.