Papaverine hydrochloride is used as a smooth muscle relaxant, with noted treatment for impotence. It can also act as a cerebral vasodilator through the possible inhibition of PDE (phosphodiesterases) and/or calcium channel actions.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Solubility
Soluble in water (50 mg/ml), DMSO, methanol, 100% ethanol and chloroform.
Notes
Light sensitive. Incompatible with oxidizing agents.
RUO – Research Use Only
H.W.Jayne; P.Scheinberg; M.Rich; M.S.Belle; Ione Blackburn. The effect of intravenous papaverine hydrochloride on the cerebral circulation. J Clin Invest. 1952, 31,(1), 111-114.
John S.Meyer, MD; Fumio Gotoh, MD; John Gilroy, MD; Nasaharu Nara, MD. Improvement in brain oxygenation and clinical improvement in patients with strokes treated with papaverine hydrochloride. JAMA. 1965, 194,(9), 957-961.