5-(Trifluoromethoxy)isatin is used as a reactant for preparation of oxindole derivatives as TAk1 kinase inhibitors and of isatin thiosemicarbazones via condensation with thiosemicarbazones as herpes simplex virus (HSV) inhibitors. It is also used as a reactant for synthesis of 3-substituted 2-indolinone RET kinase inhibitors and for preparation of indolone acetamides as antiseizure agents.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
5-(Trifluoromethoxy)isatin is used as a reactant for preparation of oxindole derivatives as TAk1 kinase inhibitors and of isatin thiosemicarbazones via condensation with thiosemicarbazones as herpes simplex virus (HSV) inhibitors. It is also used as a reactant for synthesis of 3-substituted 2-indolinone RET kinase inhibitors and for preparation of indolone acetamides as antiseizure agents.
Solubility
Insoluble in water.
Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
RUO – Research Use Only
Anne Frycia; Jean-Philippe Starck; Sophie Jadot; Benedicte Lallemand; Karine Leclercq; Patrick Lo Brutto; Alain Matagne; Valerie Verbois; Joel Mercier; Benoit Kenda. Discovery of indolone acetamides as novel SV2A ligands with improved potency toward seizure suppression. Chemmedchem. 2010, 5,(2), 200-205.
Jeffrey W.Lockman; Matthew D.Reeder; Rosann Robinson; Patricia A.Ormonde; Daniel M.Cimbora; Brandi L.Williams; J.Adam Willardsen. Oxindole derivatives as inhibitors of TAK1 kinase. Bioorganic & Medicinal Chemistry Letters. 2011, 21,(6), 1724-1727.