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L-Homophenylalanine, 98%, Thermo Scientific Chemicals
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Catalog number H27295.14
also known as H27295-14
Price (USD)/ Each
647.00
-
Quantity:
25 g
Price (USD)/ Each
647.00
L-Homophenylalanine, 98%, Thermo Scientific Chemicals
Catalog numberH27295.14
Price (USD)/ Each
647.00
-
Chemical Identifiers
CAS943-73-7
IUPAC Name(2S)-2-amino-4-phenylbutanoic acid
Molecular FormulaC10H13NO2
InChI KeyJTTHKOPSMAVJFE-VIFPVBQESA-N
SMILESN[C@@H](CCC1=CC=CC=C1)C(O)=O
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Specifications
Specification Sheet
Specification SheetAppearance (Color)White
FormPowder
Assay (Non-aqueous acid-base Titration)≥97.5 to ≤102.5%
Water Content (Karl Fischer Titration)≤1%
Optical Rotation45.9 ± 0.3? (C=1 in 5N HCl)
L-Homophenylalanine is used as a precursor in the pharmaceutical industry for the production of angiotensin-converting enzyme (ACE) and R-(-)-Homophenylalanin-ethylester. It is also involved in the synthesis of NEPA [(S,S)-N-(1-Ethoxycarbonyl-3-phenylpropyl)alanine], which is a key intermediate to prepare the ACE-inhibitors: enalapril, delapril, quinapril and ramipril. It acts as an anti-tumor reagent.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
L-Homophenylalanine is used as a precursor in the pharmaceutical industry for the production of angiotensin-converting enzyme (ACE) and R-(-)-Homophenylalanin-ethylester. It is also involved in the synthesis of NEPA [(S,S)-N-(1-Ethoxycarbonyl-3-phenylpropyl)alanine], which is a key intermediate to prepare the ACE-inhibitors: enalapril, delapril, quinapril and ramipril. It acts as an anti-tumor reagent.
Solubility
Soluble in dilute aqueous acid.
Notes
Store in cool place. Incompatible with strong oxidizing agents, strong acids and bases.
L-Homophenylalanine is used as a precursor in the pharmaceutical industry for the production of angiotensin-converting enzyme (ACE) and R-(-)-Homophenylalanin-ethylester. It is also involved in the synthesis of NEPA [(S,S)-N-(1-Ethoxycarbonyl-3-phenylpropyl)alanine], which is a key intermediate to prepare the ACE-inhibitors: enalapril, delapril, quinapril and ramipril. It acts as an anti-tumor reagent.
Solubility
Soluble in dilute aqueous acid.
Notes
Store in cool place. Incompatible with strong oxidizing agents, strong acids and bases.
RUO – Research Use Only
General References:
- Zhang, J.; Tao, S.; Zhang, B.; Wu, X.; Chen, Y. Microparticle-based strategy for controlled release of substrate for the biocatalytic preparation of L-homophenylalanine. ACS Catal. 2014, 4 (5), 1584-1587.
- Zhang, J.; Zhu, T.; Wu, X.; Chen, Y. Enhancement of biocatalytic efficiency by increasing substrate loading: enzymatic preparation of L-homophenylalanine. Appl. Microbiol. Biotechnol. 2013, 97 (19), 8487-8494.