1-Aza-18-crown-6 is used as building block for the synthesis of bis-crown ethers, lariat ethers and other monofunctionalized macrocycles. It is also used as pharmaceutical intermediate.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
1-Aza-18-crown-6 is used as building block for the synthesis of bis-crown ethers, lariat ethers and other monofunctionalized macrocycles. It is also used as pharmaceutical intermediate.
Solubility
Insoluble in water.
Notes
Air sensitive. Store away from oxidizing agents.
RUO – Research Use Only
General References:
- Kamaluddin Abdur-Rashid; Dmitry G.Gusev; Alan J.Lough; Robert H.Morris. Intermolecular proton-hydride bonding in ion pairs: Synthesis and structural properties of [K(Q)][MH5(PiPr3)2] (M = Os, Ru; Q = 18-crown-6, 1-aza-18-crown-6, 1,10-diaza-18-crown-6). Organometallics. 2000, 19, (5),834-843
- Huimin Luo; Sheng Dai; Peter V.Bonnesen. Solvent extraction of Sr2+ and Cs+ based on room-temperature ionic liquids containing monoaza-substituted crown ethers. Anal. Chem. 2004, 76, (10),2773-2779