Isopropyl magnesium chloride is used primarily to add an iso-propyl group to carbonyl groups. This reagent can also be used as a strong base in aprotic solvents.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Isopropyl magnesium chloride is used primarily to add an iso-propyl group to carbonyl groups. This reagent can also be used as a strong base in aprotic solvents.
Solubility
It reacts violently with water.
Notes
Air & moisture sensitive. Incompatible with oxidizing agents and bases.
RUO – Research Use Only
Shimpei Sugiyama; Hitomi Shimizu; Tsuyoshi Satoh. The first example of γ-chloromagnesio γ-lactones: their generation from γ-tolylsulfinyl γ-lactones with isopropylmagnesium chloride, stability, and reaction with electrophiles. Tetrahedron Letters. 2006, 47, (49),8771-8775
Juan de M.Munoz; Jesus Alcazar; Antonio de la Hoz; Angel Diaz-Ortiz; Sergio-A. Alonso de Diego. Preparation of amides mediated by isopropylmagnesium chloride under continuous flow conditions. Green Chem. 2012, 14, (5),1335-1341