(Boc-aminooxy)acetic acid was employed to introduce a hydroxylamine moiety into peptides; reaction with an aldehyde to an oxime. It was used in the preparation of Boc-aminooxy tetra(ethylene glycol).
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Applications
(Boc-aminooxy)acetic acid was employed to introduce a hydroxylamine moiety into peptides; reaction with an aldehyde to an oxime. It was used in the preparation of Boc-aminooxy tetra(ethylene glycol).
Solubility
Soluble in methanol.
Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents.
RUO – Research Use Only
General References:
- Karen L.Christman; Rebecca M.Broyer; Zachary P.Tolstyka; Heather D.Maynard. Site-specific protein immobilization through N-terminal oxime linkages. J. Mater. Chem. 2007, 17, (19),2021-2027
- Damien Forget; Dr. Didier Boturyn; Dr. Eric Defrancq; Prof. Jean Lhomme; Prof. Pascal Dumy. Highly efficient synthesis of peptide-oligonucleotide conjugates: Chemoselective oxime and thiazolidine formation. Chemistry - A European Journal. 2001, 7, (18),3976-3984