Agmatine is an intermediate in the biosynthesis of the polyamines putrescine and spermine. Agmatine binds with high affinity to α2-adrenergic receptors and imidazoline binding sites and produces blockade of the NMDA-receptor associated cation channels. Agmatine is a competitive inhibitor of nitric oxide synthase activity owing to mimicry of the natural NOS substrate arginine.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Agmatine is an intermediate in the biosynthesis of the polyamines putrescine and spermine. Agmatine binds with high affinity to α2-adrenergic receptors and imidazoline binding sites and produces blockade of the NMDA-receptor associated cation channels. Agmatine is a competitive inhibitor of nitric oxide synthase activity owing to mimicry of the natural NOS substrate arginine.
Solubility
Soluble in water, nearly insoluble in alcohol
Notes
Keep container tightly closed. Store away from oxidizing agents.
RUO – Research Use Only
General References:
- Yoko Sakakibara.; Hiroshi Yanagisawa. Agmatine deiminase from cucumber seedlings is a mono-specific enzyme: purification and characteristics. Protein Expression and Purification. 2003, 30, (1), 88-93.
- Kazuho Abe.; Yuzuru Abe.; Hiroshi Saito. Agmatine suppresses nitric oxide production in microglia. Brain Research. 2000, 872, (1-2), 141-148.