5-Chlorovaleroyl chloride (5-CVC) has been used in the development and validation of a GC-FID method for the analysis of low level impurities present in 5-CVC. It has been used in the synthesis of anion-exchange resins by acylation of polystyrene/divinylbenzene and subsequent amination with trimethylamine. It is commonly used as alkylating agent in the synthesis of pharmaceutical intermediates and other specialty chemicals.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
5-Chlorovaleroyl chloride (5-CVC) has been used in the development and validation of a GC-FID method for the analysis of low level impurities present in 5-CVC. It has been used in the synthesis of anion-exchange resins by acylation of polystyrene/divinylbenzene and subsequent amination with trimethylamine. It is commonly used as alkylating agent in the synthesis of pharmaceutical intermediates and other specialty chemicals.
Solubility
Reacts with water.
Notes
Moisture sensitive. Incompatible with oxidizing agents, bases, alcohols, amines.
RUO – Research Use Only
Liya Tang.; Alexandre Kim.; Scott A. Miller.; David K. Lloyd. Development and validation of a specific and sensitive GC-FID method for the determination of impurities in 5-chlorovaleroyl chloride.J. Pharm. Biomed. Anal. 2010, 53 (3), 309-314.
T. N. Kas’yanova.; A. D. Smolenkov.; A. V. Pirogov.; O. A. Shpigun. Effect of the acylating agent on the selectivity of anion-exchange resins and separation efficiency. Moscow University Chemistry Bulletin. 2007, 62 (5), 286-289.