2-(4-Fluorophenyl)ethylamine may be employed as nucleophile in the synthesis of 2-amino-4-arylpyrimidine derivatives. It is suitable for use in the preparation of ortho-metalated primary phenethylamines having electron-releasing and electron-withdrawing groups on the aromatic ring, leading to complexes containing six membered palladacycles.
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Applications
2-(4-Fluorophenyl)ethylamine may be employed as nucleophile in the synthesis of 2-amino-4-arylpyrimidine derivatives. It is suitable for use in the preparation of ortho-metalated primary phenethylamines having electron-releasing and electron-withdrawing groups on the aromatic ring, leading to complexes containing six membered palladacycles.
Solubility
Slightly soluble in water.
Notes
Stable under recommended storage conditions. Incompatible with oxidizing agents and acids.
RUO – Research Use Only
General References:
- Mitra Matloobi; C.Oliver Kappe. Microwave-assisted solution- and solid-phase synthesis of 2-amino-4-arylpyrimidine derivatives. Journal of Combinatorial Chemistry. 2007, 9,(2), 275-284.
- Jose Vicente; Isabel Saura-Llamas; Jesus Cuadrado; Carmen Ramirez de Arellano. Ortho-metalated primary amines. 6.1 The first synthesis of six-membered palladacycles from primary amines containing electron-withdrawing substituents: end of the limiting rules of Cope and Friedrich on cyclopalladation of benzyl-and phenethylamines. Organometallics. 2003, 22,(26), 5513-5517.