2-Bromo-6-chlorobenzaldehyde plays an important role as a linker, which provides higher selectivity and reactivity in the Buchwald C-N bond forming reaction in order to prepare Bruton's tyrosine kinase inhibitor.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
2-Bromo-6-chlorobenzaldehyde plays an important role as a linker, which provides higher selectivity and reactivity in the Buchwald C-N bond forming reaction in order to prepare Bruton′s tyrosine kinase inhibitor.
Solubility
Slightly soluble in water.
Notes
Store in a cool place. Air sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong oxidizing agents.
RUO – Research Use Only
Sahn, J. J.; Su, J. Y.; Martin, S. F. Facile and unified approach to skeletally diverse, privileged scaffolds. Org. Lett. 2011, 13 (10), 2590-2593.
Donald, J. R.; Granger, B. A.; Hardy, S.; Sahn, J. J.; Martin, S. F. Applications of Multicomponent Assembly Processes To the Facial Synthesis of Diversely Functionalized Nitrogen Heterocycles. Heterocycles 2012, 84 (2), 1089.