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Difluoromethyl phenyl sulfone, 95%, Thermo Scientific Chemicals
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Catalog number H64760.03
also known as H64760-03
Price (USD)/ Each
77.00
-
Quantity:
1 g
Price (USD)/ Each
77.00
Difluoromethyl phenyl sulfone, 95%, Thermo Scientific Chemicals
Catalog numberH64760.03
Price (USD)/ Each
77.00
-
Chemical Identifiers
CAS1535-65-5
IUPAC Namedifluoromethanesulfonylbenzene
Molecular FormulaC7H6F2O2S
InChI KeyLRHDNAVPELLXDL-UHFFFAOYSA-N
SMILESFC(F)S(=O)(=O)C1=CC=CC=C1
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Specifications
Specification Sheet
Specification SheetAssay (HPLC)>94.0%
Used as a reagent for the nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls and fluorination. Reagent used for reductive silylation and the preparation of trifluoro- and difluoromethylsilanes by reductive coupling of fluoromethyl sulfones, sulfoxides and sulfides with chlorosilanes, fluoroalkylation/chloroalkylation of α,β-enones, arynes, acetylenic ketones and other Michael acceptors, difluoromethylation of primary alkyl halides via nucleophilic substitution-reductive desulfonylation. Also used as reagent in preparation of α-difluoromethyl amines via stereo selective (phenylsulfonyl)difluoromethylation of chiral sulfinyl aldimines and Anti-difluoropropanediols via potassium tert-butoxide-catalyzed difluoromethylenation of aldehydes.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
Used as a reagent for the nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls and fluorination. Reagent used for reductive silylation and the preparation of trifluoro- and difluoromethylsilanes by reductive coupling of fluoromethyl sulfones, sulfoxides and sulfides with chlorosilanes, fluoroalkylation/chloroalkylation of α,β-enones, arynes, acetylenic ketones and other Michael acceptors, difluoromethylation of primary alkyl halides via nucleophilic substitution-reductive desulfonylation. Also used as reagent in preparation of α-difluoromethyl amines via stereo selective (phenylsulfonyl)difluoromethylation of chiral sulfinyl aldimines and Anti-difluoropropanediols via potassium tert-butoxide-catalyzed difluoromethylenation of aldehydes.
Solubility
Soluble in chloroform and water.
Notes
Keep container tightly closed. With adequate ventilation. Store away from oxidizing agent.
Used as a reagent for the nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls and fluorination. Reagent used for reductive silylation and the preparation of trifluoro- and difluoromethylsilanes by reductive coupling of fluoromethyl sulfones, sulfoxides and sulfides with chlorosilanes, fluoroalkylation/chloroalkylation of α,β-enones, arynes, acetylenic ketones and other Michael acceptors, difluoromethylation of primary alkyl halides via nucleophilic substitution-reductive desulfonylation. Also used as reagent in preparation of α-difluoromethyl amines via stereo selective (phenylsulfonyl)difluoromethylation of chiral sulfinyl aldimines and Anti-difluoropropanediols via potassium tert-butoxide-catalyzed difluoromethylenation of aldehydes.
Solubility
Soluble in chloroform and water.
Notes
Keep container tightly closed. With adequate ventilation. Store away from oxidizing agent.
RUO – Research Use Only
General References:
- G K Surya Prakash; Jinbo Hu; George A Olah. Preparation of tri- and difluoromethylsilanes via an unusual magnesium metal-mediated reductive tri- and difluoromethylation of chlorosilanes using tri- and difluoromethyl sulfides, sulfoxides, and sulfones. Journal of Organic Chemistry.2003 68(11), 4457-4463.
- Chuanfa Ni; Laijun Zhang; Jinbo Hu. Nucleophilic fluoroalkylation of alpha,beta-enones, arynes, and activated alkynes with fluorinated sulfones: probing the hard/soft nature of fluorinated carbanions. Journal of Organic Chemistry.2008 73(15), 5699-5713.