1-Propylphosphonic acid cyclic anhydride is used as a reagent for amide/peptide bond formation. It is utilized for condensation reactions and alcohol oxidations. It is also used to promote the synthesis of hydroxamic acids from carboxylic acids. Further, it is employed as an efficient promoter for the Lossen rearrangement to synthesis urea and carbamate derivatives.
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Applications
1-Propylphosphonic acid cyclic anhydride is used as a reagent for amide/peptide bond formation. It is utilized for condensation reactions and alcohol oxidations. It is also used to promote the synthesis of hydroxamic acids from carboxylic acids. Further, it is employed as an efficient promoter for the Lossen rearrangement to synthesis urea and carbamate derivatives.
Solubility
Miscible with dioxane, terahydrofuran, dimethyl formamide, polar and aprotic organic solvents.
Notes
Moisture sensitive. Incompatible with strong oxidizing agents.
RUO – Research Use Only
Madhu, C.; Basavaprabhu.; Vishwanatha, T. M.; Sureshbabu, V. V. T3P (propylphosphonic anhydride) mediated conversion of Nα-protected amino/peptide acids into thioacids. Tetrahedron Lett. 2012, 53 (11), 1406-1409.
Nagendra, G.; Madhu, C.; Vishwanatha, T. M.; Sureshbabu, V. V. An expedient route for the reduction of carboxylic acids to alcohols employing 1-propanephosphonic acid cyclic anhydride as acid activator. Tetrahedron Lett. 2012, 53 (38), 5059-5063.
Prasanna, T. S. R.; Raju, K. M. Quick Access to Bis(indolyl)methanes: T3P as a Novel Catalyst System. J. Korean Chem. Soc. 2012, 56 (1), 1406-1409.