Naloxone hydrochloride, 98%, Thermo Scientific Chemicals
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Naloxone hydrochloride, 98%, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Naloxone hydrochloride, 98%, Thermo Scientific Chemicals

Naloxone hydrochloride, CAS # 357-08-4, is involved in the blockade of the mu-opioid receptor and removal of other compounds from the receptor site.
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Catalog number J60013.MC
also known as J60013-MC
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100 mg
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Price (USD)/ Each
72.65
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Online exclusive
Ends: 31-Dec-2024
85.80 
Save 13.15 (15%)
Add to cart
Naloxone hydrochloride, 98%, Thermo Scientific Chemicals
Catalog numberJ60013.MC
Price (USD)/ Each
72.65
Special Offer
Online exclusive
Ends: 31-Dec-2024
85.80 
Save 13.15 (15%)
-
Add to cart
Chemical Identifiers
CAS357-08-4
IUPAC Namehydrogen (1S,5R,13R,17S)-10,17-dihydroxy-4-(prop-2-en-1-yl)-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7,9,11(18)-trien-14-one chloride
Molecular FormulaC19H22ClNO4
InChI KeyRGPDIGOSVORSAK-STHHAXOLSA-N
SMILES[H+].[Cl-].OC1=CC=C2C[C@H]3N(CC=C)CC[C@@]45[C@@H](OC1=C24)C(=O)CC[C@@]35O
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SpecificationsSpecification SheetSpecification Sheet
Appearance (Color)White to pale cream
Assay from Suppliers CofA≥97.5% (dry wt.)
Loss on Drying≤11.0%
Optical Rotation-170.5° ±5.5°
FormCrystals or powder or crystalline powder
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A specific opiate antagonist. Blocks the action of sigma-agonists at opioid sites.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description
• Naloxone hydrochloride the hydrochloride salt of the anti-opioid naloxone
Application
• Naloxone is a fast-acting inverse agonist of the mu-opioid receptor that can be used to competitively inhibit the binding of opioid compounds
RUO – Research Use Only

General References:

  1. Meng F, Li Y, Sun H, Li C, Li Q, Law PY, Loh HH, Liang L, Zheng H. Naloxone Facilitates Contextual Learning and Memory in a Receptor-Independent and Tet1-Dependent Manner. Cell Mol Neurobiol. 2021 Jul;41(5):1031-1038. doi: 10.1007/s10571-020-00970-8. Epub 2020 Sep 28. PMID: 32989585.
  2. Chen J, Liang L, Li Y, Zhang Y, Zhang M, Yang T, Meng F, Lai X, Li C, He J, He M, Xu Q, Li Q, Law PY, Loh HH, Pei D, Sun H, Zheng H. Naloxone regulates the differentiation of neural stem cells via a receptor-independent pathway. FASEB J. 2020 Apr;34(4):5917-5930. doi: 10.1096/fj.201902873R. Epub 2020 Mar 10. PMID: 32154623.