Everolimus, Thermo Scientific Chemicals
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Everolimus, Thermo Scientific Chemicals
Thermo Scientific Chemicals

Everolimus, Thermo Scientific Chemicals

A rapamycin analog
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Catalog number J60139.LB0
also known as J60139-#0
Price (USD)/ Each
175.00
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Quantity:
5 mg
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Price (USD)/ Each
175.00
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Everolimus, Thermo Scientific Chemicals
Catalog numberJ60139.LB0
Price (USD)/ Each
175.00
-
Add to cart
Chemical Identifiers
CAS159351-69-6
IUPAC Name(1R,9S,12S,15R,16Z,18R,19R,21R,23S,24E,26Z,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.0⁴,⁹]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone
Molecular FormulaC53H83NO14
InChI KeyHKVAMNSJSFKALM-CNPAPGRKSA-N
SMILESCO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC(=O)[C@H](C)C=C(C)/[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)C=CC=C/C=C(C)/[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N3CCCC[C@H]3C(=O)O2)OC)CC[C@H]1OCCO
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SpecificationsSpecification SheetSpecification Sheet
FormPowder or crystals or crystalline powder or granules or amorphous solid
Appearance (Color)White to off-white to pale yellow
Assay from Suppliers CofA≥95.0%
Everolimus is a rapamycin analog. It is used to treat certain types of kidney cancer, breast cancer and brain tumor. It prevents transplant rejection by decreasing the activity of the immune system. It also act as a kinase inhibitor. It is used in the treatment of subependymal giant cell astrocytoma (SEGA; a type of brain tumor) in adults and children 1 year of age and older who have TSC.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Solubility
Soluble in dimethysulfoxide,ethanol and chloroform. Slightly soluble in water.

Notes
Incompatible with strong oxidizing agents.
RUO – Research Use Only

General References:

  1. Puricel, S.; Arroyo, D.; Corpataux N.; Baeriswyl, G.; Lehmann, N.; Kallinikou, Z.; Muller, O.; Allard, L.; Stauffer, J.; Togni, M.; Goy, J.; Cook, S. Comparison of Everolimus- and Biolimus-Eluting Coronary Stents With Everolimus-Eluting Bioresorbable Vascular Scaffolds. J. Am. Coll. Cardiol. 2015, 65 (8), 791-801.
  2. Naruse, T.; Yanamoto, S.; Yamada, S.; Rokutanda, S.; Kawakita, A.; Kawasaki, G.; Umeda, M. Anti-Tumor Effect of the Mammalian Target of Rapamycin Inhibitor Everolimus in Oral Squamous Cell Carcinoma. Pathol. Oncol. Res. 2015, 21 (3), 765-773.